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ECSIT蛋白抗体
产品名称 | 英文名称 | 货号 |
ECSIT蛋白抗体 | ECSIT | GOY-01K2497 |
商品属性:
英文名称: ECSIT
中文名:ECSIT蛋白抗体
别 名;Ecsit; ECSIT
homolog; ECSIT protein; ECSIT_HUMAN; Evolutionarily conserved signaling
intermediate in Toll pathway; Evolutionarily conserved signaling intermediate
in Toll pathway, mitochondrial; Evolutionarily conserved signaling intermediate
in Toll pathways; Likely ortholog of mouse signaling intermediate in Toll
pathway evolutionarily conserved; Protein SITPEC; Signaling intermediate in
Toll pathway evolutionarily conserved; SITPEC; SITPEC protein.
研究领域;细胞生物 免疫学 信号转导
抗体来源;Rabbit
克隆类型;Polyclonal
交叉反应;(predicted:
Human, Mouse, Rat, Dog, Cow, Sheep, )
产品应用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量;44kDa
细胞定位;细胞核 细胞浆
性 状;Liquid
浓 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human ECSIT: 101-200/431
亚 型;IgG
纯化方法;affinity
purified by Protein A
缓 冲 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
ECSIT is a 431 amino acid ubiquitously expressed
protein that plays an important role as an adaptor protein in the cytosolic
signal transduction cascade events triggered by Toll receptor activation.
Within the Toll pathway, ECSIT regulates MEKK1 processing for activation of
NFκB, a major event leading to
initiation of the innate immune response. In the mitochondria, ECSIT
interacts with NDUFAF1 and assists in the formation of NADH:ubiquinone
oxidoreductase (complex I), an extremely complicated multiprotein complex
located in the inner mitochondrial membrane that functions in the transport
of electrons from NADH to ubiquinone. Knockdown of ECSIT results in severely
impaired complex I assembly and disturbed mitochondrial function. There are
two isoforms of ECSIT that are produced as a result of alternative splicing
events Function: Adapter protein of the Toll-like and IL-1 receptor
signaling pathway that is involved in the activation of NF-kappa-B via
MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP
signaling pathway. Required for normal embryonic development (By similarity).
Required for efficient assembly of mitochondrial NADH:ubiquinone
oxidoreductase. |
多克隆抗体制备:
我公司合成抗原,保证阳性血清和抗体ELISA效价达到1:32000,由蛋白抗原制备的多抗,保证WB检测结果是阳性。技术服务实行分步报价,按节点收费,为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行,我公司将为您的项目提供专业的建议。在制备过程中,与客户互动验证,确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时,也能满足客户抗体最终应用验证需求。技术服务实行分步报价,按节点收费,为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能,而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台,能为客户提供各种类型的重组抗体表达服务,包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达,抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务,如动物免疫、动物饲养、抗体修饰服务(如FITC,HRP等的标记)、以及ELISA,WB,IHC,DB等检测服务。
抗体定制服务:
已注册商标,主要用于抗体药物发现和开发,是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务,主要面向工业客户。
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